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Micro And Macrovascular Complications Of Diabetes Pdf Journals

micro and macrovascular complications of diabetes pdf journals

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Diabetes complications contribute to reduction in health-related quality of life of patients and increased health resources usage. Mean age of study population was Majority were females Above half of the patients

Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?

Metrics details. The global prevalence of type 2 diabetes-related complications is not well described. We assessed prevalence of vascular complications at baseline in DISCOVER NCT; NCT , a global, prospective, observational study program of 15, patients with type 2 diabetes initiating second-line therapy, conducted across 38 countries. Patients were recruited from primary and specialist healthcare settings. Data were collected using a standardized case report form. Prevalence estimates of microvascular and macrovascular complications at baseline were assessed overall and by country and region, and were standardized for age and sex.

Microvascular and Macrovascular Complications of Diabetes

To determine the prevalence of vascular complications among inpatients with type 2 diabetes mellitus T2DM and factors independently associated with vascular complications in a tertiary care department in Ningbo, China, the authors conducted a cross-sectional study using an existing computerised medical records database. A total of adult patients with T2DM were admitted to this tertiary care department for the first time between and Patients were categorised as those 1 with at least one vascular complication, 2 with at least one microvascular complication, and 3 with at least one macrovascular complication. Over 5 years, the prevalence of vascular, microvascular, and macrovascular complications among inpatients with T2DM was The odds of vascular, microvascular, and macrovascular complications increased with age and were higher in patients with hypertension. The odds of vascular and microvascular complications were higher in single, divorced, or widowed patients, patients with T2DM for a long time, and patients on advanced T2DM therapeutic regimen.

Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum? Diabetes and related complications are associated with long-term damage and failure of various organ systems. The line of demarcation between the pathogenic mechanisms of microvascular and macrovascular complications of diabetes and differing responses to therapeutic interventions is blurred. Diabetes induces changes in the microvasculature, causing extracellular matrix protein synthesis, and capillary basement membrane thickening which are the pathognomic features of diabetic microangiopathy. These changes in conjunction with advanced glycation end products, oxidative stress, low grade inflammation, and neovascularization of vasa vasorum can lead to macrovascular complications. Hyperglycemia is the principal cause of microvasculopathy but also appears to play an important role in causation of macrovasculopathy. There is thought to be an intersection between micro and macro vascular complications, but the two disorders seem to be strongly interconnected, with micro vascular diseases promoting atherosclerosis through processes such as hypoxia and changes in vasa vasorum.

Micro- and Macrovascular Complications in Diabetes Mellitus: Preclinical and Clinical Studies

Diabetes and related complications are associated with long-term damage and failure of various organ systems. The line of demarcation between the pathogenic mechanisms of microvascular and macrovascular complications of diabetes and differing responses to therapeutic interventions is blurred. Diabetes induces changes in the microvasculature, causing extracellular matrix protein synthesis, and capillary basement membrane thickening which are the pathognomic features of diabetic microangiopathy.

To conduct a prospective study in patients with type 2 diabetes mellitus T2DM with no microvascular complications, analyzing the association between various baseline risk factors and development of microvascular complications at follow-up.. A prospective, observational study in patients with T2DM enrolled in Baseline variables included age, gender, duration of T2DM, fasting plasma glucose, glycated hemoglobin HbA 1c , systolic and diastolic blood pressure, body weight, height, body mass index, waist circumference, total cholesterol, triglycerides, high density lipoprotein cholesterol HDL-C , low density lipoprotein cholesterol LDL-C , high sensitive C-reactive protein hs-CRP , fibrinogen, UAE, creatinine, smoking status, exercise, alcohol consumption, use of hypoglycemic and lipid-lowering drugs, antihypertensive medications, and other data related to family history of diabetes and risk factors..

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Fowler Published Medicine Clinical Diabetes. Diabetes is a group of chronic diseases characterized by hyperglycemia. Modern medical care uses a vast array of lifestyle and pharmaceutical interventions aimed at preventing and controlling hyperglycemia. In addition to ensuring the adequate delivery of glucose to the tissues of the body, treatment of diabetes attempts to decrease the likelihood that the tissues of the body are harmed by hyperglycemia.

Diabetes mellitus DM is a worldwide public health problem that affects millions of people from all age, gender, and racial and ethnic groups. DM is the leading cause of blindness and amputation and contributes substantially to kidney disease, cardiomyopathy, and cerebrovascular and peripheral artery diseases. Of importance, recent advances in biology and medicine have introduced new technologies to study the molecular pathology underlying DM-related complications, the development of novel strategies to treat these conditions, and the evaluation of outcomes. The present special issue has been designed to stimulate the continuing efforts to develop novel drugs and therapeutic targets and new perspectives of combined therapies for decreasing micro- and macrovascular complications in DM.


mydowntownsmyrna.org). Diabetes is a injury. Microvascular Complications of. Diabetes. Diabetic retinopathy lar outcomes in people with diabetes mellitus.


Background

Micro and macrovascular complications of diabetes mellitus in cameroon: risk factors and effect of diabetic check-up - a monocentric observational study. Introduction: The objective of this study was to evaluate the prevalence of vascular complications among diabetes patients DP , to find out the relationship with risk factors and to assess the effect of diabetic check-up DC in the onset of these complications. Methods: Clinical and laboratory data of DP followed between and were retrospectively analyzed. Those with at least one DC were selected out of Risk factors were checked and listed.

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