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Liraglutide And Renal Outcomes In Type 2 Diabetes Pdf

liraglutide and renal outcomes in type 2 diabetes pdf

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Published: 02.06.2021

NEJM Journal Watch

Study record managers: refer to the Data Element Definitions if submitting registration or results information. Administered in addition to the subject's standard treatment Placebo Comparator: Placebo Drug: placebo Maximum dose of 1. The percentage of subjects experiencing a first event of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke a composite cardiovascular outcome is presented. The percentage of subjects experiencing first occurrence of an expanded composite cardiovascular outcome defined as either cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularisation, hospitalisation for unstable angina or for heart failure is presented. The percentage of subjects with a death by any cause all-cause death is presented.

Erweiterte Suche. Springer Medizin. Wichtige Hinweise. Abstract The development of chronic kidney disease CKD in people with diabetes is commonplace, and is frequently associated with a significant and unfavourable impact on patient outcomes along with a substantial economic burden. With the development of novel classes of drug therapies in diabetes, there has been a recent focus on cardiovascular safety measures, with dedicated cardiovascular outcome trials CVOTs carried out for all new diabetes medications. More recently, there has been a growing regulatory view that such trials should report more specific renal outcomes to ensure simpler comparability between drugs and drug classes.

Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER®)

Allan S. N Engl J Med Aug Now, the researchers report renal outcomes. At baseline, participants' mean age was 64, mean glycosylated hemoglobin HbA 1c was 8. During average follow-up of 4 years, incidence of a combined renal endpoint new-onset persistent macroalbuminuria, doubling of serum creatinine, end-stage renal disease, or renal-related death was significantly lower with liraglutide than with placebo 5. New-onset persistent macroalbuminuria accounted for most of this difference. In this study of the glucagon-like peptide-1 analogue liraglutide, the 1.

Metrics details. Emerging evidence suggests that sodium-glucose cotransporter-2 SGLT-2 inhibitors and glucagon-like peptide-1 receptor agonists GLP-1 RAs are associated with decreased risk of cardiovascular and renal events in type 2 diabetes mellitus DM patients. We performed a systematic literature search through November We selected randomized control trials that compared the risk of major adverse cardiovascular events MACE and a composite of renal outcomes. Thirteen studies were selected with a total of 32, patients. Diabetes mellitus DM is a major public health problem with a high prevalence. Sodium-glucose cotransporter-2 SGLT-2 inhibitors are a new class of glucose-lowering agents.

The development of chronic kidney disease CKD in people with diabetes is commonplace, and is frequently associated with a significant and unfavourable impact on patient outcomes along with a substantial economic burden. With the development of novel classes of drug therapies in diabetes, there has been a recent focus on cardiovascular safety measures, with dedicated cardiovascular outcome trials CVOTs carried out for all new diabetes medications. More recently, there has been a growing regulatory view that such trials should report more specific renal outcomes to ensure simpler comparability between drugs and drug classes. This article explores some of the possible mechanisms by which these drugs may improve renal function in people with diabetes, and it reviews important CVOTs that have reported renal outcomes to date. The heterogeneity of patient characteristics and reported renal outcomes, which hinders comparisons between trials and drug classes, is highlighted. Novel classes of diabetes therapies present an important opportunity for nephroprotection beyond the blockade of the renin—angiotensin—aldosterone system in this high-risk group.

Renal Outcomes in Type 2 Diabetes: A Review of Cardiovascular and Renal Outcome Trials

Liraglutide and Renal Outcomes in Type 2 Diabetes. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are un - known. METHODS We report the prespecified secondary renal outcomes of that randomized, con - trolled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbumin - uria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease.

Treatment goals for these high-risk patients have changed from a focus on haemoglobin A1c HbA1c reduction to a broader approach aimed at optimizing all metabolic risk factors and reducing cardiovascular complications. About a decade ago we saw the downfall of the glitazones that had initially dawned as promising drugs in causal diabetes therapy and were largely abandoned later on due to controversial cardiovascular side effects. Subsequently, benefits of all antidiabetic therapies have been questioned, and consequently the US Food and Drug Administration FDA now requires cardiovascular safety data for every new antidiabetic drug.

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Renal Outcomes in Type 2 Diabetes: A Review of Cardiovascular and Renal Outcome Trials

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2 Comments

  1. Nancy E.

    05.06.2021 at 22:18
    Reply

    BackgroundIn a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2.

  2. Keydursune

    08.06.2021 at 14:39
    Reply

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