File Name: diversity and dialogue in immunity to helminths .zip
Publications - A, Allen, J. Parasitology : Hewitson, J. Journal of Immunology Hewitson, J. J, Grainger, J. D, Ashford, D. Maizels, R. Science : Maizels, R. Heligmosomoides polygyrus: one species still.
Trends in Parasitology 27 : Maizels, R. Advances in Immunology Eds A. Rudensky and S. Sakaguchi : Mutapi, F. Parasite Immunology 33 : Mutapi, F. PLOS One 6 5 : e Nausch, N. S, and Maizels, R. Journal of Immunology Smith, K. Nature Immunology 12 : 6 Sutherland, T. Chemistry and Biology 18 : van der Werf, N. S and Taylor, M. Journal of Immunology Publications - Artis, D.
Herbst, T. European Journal of Immunology Maizels, R. Current Opinion in Immunology 24 : Maizels, R. Experimental Parasitology : Parkinson, J. V, Sanford, C. Seminars in Immunopathology Ed. Journal of Immunology : Smith, K. Infection and Immunity Taylor, M. Trends in Immunology 33 : Wammes, L.
Sartono, E. PLOS Pathogens 9 8 : e 15 pp. Jenkins, S. Journal of Experimental Medicine McSorley, H. International Journal of Parasitology Maizels, R.
Veterinary Parasitology Maizels, R. Nature Immunology Redpath, S. European Journal of Immunology Schabussova, I. Parasites and Vectors 7 Buck, A. Nature Communications DOI: Immunology and Cell Biology 92 : Hewitson, J. Expert Review of Vaccines 13 : Hewitson, J. Transplantation 97 : Lee, S. Mucosal Immunology 7 : Maizels, R.
Helminths in the hygiene hypothesis - sooner or later? Clin Exp Immunol. Immunity 41 Reynolds, L. Journal of Immunology : Reynolds, L. Gut Microbes Smith, K. European Journal of Immunology 44 : Sotillo, J. Bouchery, T. Nature Immunology 15 :
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Parasitic worms helminths developed various immunoregulatory mechanisms to counteract the immune system of their host. The increasing identification and characterization of helminth-derived factors with strong immune modulatory activity provides novel insights into immune escape strategies of helminths. Such factors might be good targets to enhance anti-helminthic immune responses.
The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth worm parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity. Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms helminths and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here. Nature Reviews.
Key words:. Helminth infections: the great neglected tropical diseases. J Clin Invest.
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Allen and Rick M. Allen , Rick M. The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth worm parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm.
Helminth parasites are complex metazoans that belong to different taxonomic families but that collectively share the capacity to downregulate the host immune response directed toward themselves parasite-specific immunoregulation. Helminth-induced immunoregulation occurs through the induction of regulatory T cells or Th2-type cells or both. However, secreted or excreted parasite metabolites, proteins, or extracellular vesicles or a combination of these may also directly induce signaling pathways in host cells. Helminth parasites belong to a diverse group of complex metazoans from different taxonomic families. Collectively, helminth infections are a major public health problem worldwide, and recent estimates suggest that 1. There is no development of adult worms in humans. These many helminths each have significant differences in their biological life cycles along with marked variation in tissue tropism.
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Publications - A, Allen, J. Parasitology : Hewitson, J.
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